caspase – Communicable Diseases Research

Jinhua Qinggan granules attenuates acute lung injury by promotion of neutrophil apoptosis and inhibition of TLR4/MyD88/NF-κB pathway

Article

Published on 2023-01-302022-11-16
Journal: Journal of ethnopharmacology
[Category] 신종인플루엔자, 치료기술,

Low BALF CD4 T cells count is associated with extubation failure and mortality in critically ill covid-19 pneumonia

낮은 BALF CD4 T 세포 수는 중환자의 covid-19 폐렴에서 발관 실패 및 사망률과 관련이 있습니다

Article

Published on 2022-12-012022-09-11
Journal: Annals of Medicine
[Category] 바이오마커, 진단,

[키워드] affected alveolar alveolar macrophage analysed average BALF BALF CD4 T-cells count baseline Biomarker bivariate analysis Bronchoalveolar lavage fluid caspase caspase-3 cause CD4 CD4 T cell CD4 T-cell Characteristics clinical Clinical characteristics conducted COVID-19 COVID-19 patients COVID-19 pneumonia COVID-19 pneumonia patient COVID-19 pneumonia patients Critically ill critically ill COVID-19 patients Critically ill COVID-19 pneumonia D-dimer D-dimer level eight enrolled extubation failure. groups help IL-17 IL-6 immunopathology IMPROVE Indonesia intubation Invasive mechanical ventilation Laboratory lung Macrophage material Mortality no significant difference no significant differences outcome Patient performed Pneumonia profile Referral reported right lung severe pneumonia severity significant differences significantly survived T-cells Tertiary Tregs understanding was performed were measured
[DOI] 10.1080/07853890.2022.2095012 PMC 바로가기 [Article Type] Article

Lowered Quality of Life in Long COVID Is Predicted by Affective Symptoms, Chronic Fatigue Syndrome, Inflammation and Neuroimmunotoxic Pathways

긴 COVID에서 삶의 질 저하가 정동 증상, 만성 피로 증후군, 염증 및 신경 면역 독성 경로에 의해 예측됩니다

Article

Published on 2022-08-192022-09-11
Journal: International Journal of Environmental Research an
[Category] 바이오마커,

[키워드] Activation acute infection Affect Anxiety AstraZeneca Biomarker body temperature calcium caspase caspase-1 chronic chronic fatigue syndrome controls COVID COVID-19 Depression domain Effect explained fatigue fatigue syndrome female fibromyalgia Health Organization IL-18 immune Inflammation inflammatory biomarkers insulin insulin resistance life Long Long COVID Myalgic encephalomyelitis/chronic fatigue syndrome myeloperoxidase neuro-immune neurotoxicity oxidative stress oxygen oxygen saturation participant pathway Pfizer physical predicted Protein psychiatry Psychiatry. Psychological Quality Quality of life rating scales recruited Regression serum severity Sex SpO2 subsequent Switzerland vaccination variance Version World Health Organization yielding
[DOI] 10.3390/ijerph191610362 PMC 바로가기 [Article Type] Article

Reveal the Mechanisms of Yi-Fei-Jian-Pi-Tang on Covid-19 through Network Pharmacology Approach

네트워크 약리학 접근법을 통해 Covid-19에 대한 Yi-Fei-Jian-Pi-Tang의 메커니즘 공개

Article

Published on 2022-07-162022-09-11
Journal: Computational Intelligence and Neuroscience
[Category] 유전자 메커니즘,

[키워드] activated activator Adhesion Molecule AKT AKT1 Alpha Beta binding C-C motif chemokine ligand C-C motif chemokine ligand 2 cancers CASP8 caspase caspase 8 CCL2 chemokine Chinese contribute Corona Critical CXCL8 Cytoscape database demonstrated effective EGFR enhancer enrichment analysis epidermal epidermal growth factor ERBB2 Formula foundation Gene ontology genomes growth factor Herb HIF1a HMOX1 hypoxia ICAM1 IL10 IL1A IL1B IL2 IL4 IL6 ingredient inhibitor inquiry intercellular intercellular adhesion molecule interferon gamma interleukin interleukin 2 Interleukin 4 interleukin 6 JUN KEGG Kyoto Ligand MAPK3 MAPK8 mechanism Medicine mitogen-activated protein kinase MMP1 MMP3 motif MPO myeloperoxidase Necrosis network network pharmacology NFE2 NFE2L2 NFkB NFKBIA nitric oxide nitric oxide synthase NOS3 nuclear oncogene outcome p53 pathway Pathways Patient Pharmacology PPARA Protein protein kinase protein p53 protein-protein interaction receptor RELA Research Serine Stat1 STRING database subunit target target protein targets TCM TGFB1 therapeutic target threonine Timp1 TNF TP53 Traditional Traditional Chinese medicine Transcription transcription factor transforming growth factor Tumor tumor necrosis tumor necrosis factor tyrosine UniProt Virus Disease
[DOI] 10.1155/2022/1493137 PMC 바로가기 [Article Type] Article

Circulatory Exosomes from COVID-19 Patients Trigger NLRP3 Inflammasome in Endothelial Cells

COVID-19 환자의 순환 엑소좀은 내피 세포에서 NLRP3 인플라마좀을 유발합니다

Article

Published on 2022-06-282022-09-11
Journal: mBio
[Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단,

[키워드] Activation of caspase-1 acute respiratory syndrome acute respiratory syndrome coronavirus augmentation blood flow cargo caspase caspase-1 Cell Circulatory Coagulation Coagulopathy combating Control coronavirus coronavirus 2 COVID-19 Culture culture medium Cytokine storm demonstrated drug endothelial Endothelial cell endothelial cells ENhance examined Exosome Exosomes exposure to extracellular vesicle Extracellular vesicles Health health problem healthy donors help highlight IL-1β Immunopathogenesis induce Infection Inflammasome inflammasome. Inflammation Inflammatory response inhibit interleukin interleukin-1β investigator liver mechanism medium Mild Mild disease molecular molecular mechanism mRNA expression Multiple organ damage NLRP3 NLRP3 inflammasome opens organ organ damage Pathogenesis Patient plasma predicted Prevent respiratory resting resulting SARS-CoV-2 SARS-COV-2 infection secretion Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 patient severe COVID-19 patients significantly the vaccine Therapies Trigger Vaccine Venous Thromboembolism with mild disease
[DOI] 10.1128/mbio.00951-22 PMC 바로가기 [Article Type] Article

Cytokeratin 18 cell death assays as biomarkers for quantification of apoptosis and necrosis in COVID-19: a prospective, observational study

COVID-19에서 세포자멸사 및 괴사의 정량화를 위한 바이오마커로서의 Cytokeratin 18 세포 사멸 분석: 전향적 관찰 연구

Observational Study

Published on 2022-06-012022-09-11
Journal: Journal of Clinical Pathology
[Category] Coronavirus, COVID19(2023년), MERS, SARS, 바이오마커, 임상,

[키워드] admitted patients Adult patients Apoptosis appear assays Biomarker blood sample Blood samples Care caspase cell damage cell death clinical trials collected Control controls COVID-19 COVID-19 patient COVID-19 patients cytokeratin discharged patients elevated emergency department enrolled enzyme epithelial epithelial cell estimation hospitalisation hospitalised hospitalised COVID-19 patients ICU admission independent predictor independent predictors Intact intensive care unit mechanism multivariable logistic regression Necrosis non-ICU Patient patients patients with COVID-19 presenting quantification relative contribution relative contributions respiratory respiratory symptom respiratory symptoms risk stratification SARS-CoV-2 severe disease sick therapeutic efficacy Trigger triggers Virology Virology.
[DOI] 10.1136/jclinpath-2020-207242 PMC 바로가기 [Article Type] Observational Study

Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis

Caspase-4/11은 염증 및 면역 혈전증을 촉진하여 SARS-CoV-2 감염의 질병 중증도를 악화시킵니다.

Article

Published on 2022-05-242022-09-12
Journal: Proceedings of the National Academy of Sciences of
[Category] COVID19(2023년), MERS, SARS, 진단,

[키워드] accumulated acute respiratory syndrome Blood CASP4 caspase caspase-11 Coagulopathy coronavirus CXCL1 detrimental disease severity downstream drug target effective endothelial damage exacerbate expressed expression Factor functions gene signature GSDMD Health homolog humans IL-6 immunothrombosis Infection Inflammation Inflammatory inflammatory mediator Innate immunity less lung Lung pathology Lungs maintain marker mice molecular target neutrophil new treatment strategy pathway promote protein level reduced SARS-COV-2 infection SARS–CoV-2 severe COVID-19 severity targeting therapeutic thrombosis thrombosis. transcription factor transcriptomics Treatment up-regulated Vascular vessel viral titer von Willebrand factor weight loss wild-type
[DOI] 10.1073/pnas.2202012119 PMC 바로가기 [Article Type] Article

Cytokine cascade in Kawasaki disease versus Kawasaki-like syndrome

가와사키병 대 가와사키 유사 증후군의 사이토카인 캐스케이드

Review

Published on 2022-03-252022-09-11
Journal: Physiological research
[Category] SARS, 유전자 메커니즘,

[키워드] acquired heart disease acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Aneurysm autoantibody Autoimmunity cardiovascular complications cascade caspase caspase 3 cause caused Cell Characteristics characterized children Coronary artery coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine cytokine level Cytokine release syndrome Cytokine storm Cytokines defined Diagnosis Factor febrile FIVE Genetic heart disease hypercytokinemia Hyperinflammatory Hypothesis IFN-gamma IL-10 IL-2 IL-4 IL-6 immunothrombosis induce Infection Inflammatory Kawasaki disease Kawasaki-like syndrome medium MIS-C myocarditis occur Pathogenesis pathogenic mechanism pathophysiology pediatric PIMS protocol respiratory virus respiratory viruses SARS-CoV-2 severe acute respiratory syndrome Coronavirus Shock susceptibility syndrome systemic inflammatory response systemic vasculitis the disease TNF-alpha Treatment triggered Vasculitis vessel
[DOI] 10.33549/physiolres.934672 PMC 바로가기 [Article Type] Review

The evaluation of both the expression and serum protein levels of Caspase-3 gene in patients with different degrees of SARS-CoV2 infection

SARS-CoV2 감염 정도가 다른 환자에서 Caspase-3 유전자의 발현 및 혈청 단백질 수준 평가

Article

Published on 2022-03-012022-09-11
Journal: Journal of medical virology
[Category] SARS, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Blood C-reactive protein C-reactive protein (CRP CASP3 CASP3 gene caspase caspase-3 caused cellular homeostasis cellular homeostasis. Concentration coronavirus evaluate the effect examined expression female ferritin Gene Expression gene expression level group hemoglobin Hemogram individual Infection information Injury Lactate lactate dehydrogenase male Patient patients Prevent SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 infection Serum level serum levels Serum protein serum sample serum samples severe acute respiratory syndrome Coronavirus severity Significant significant differences statistically significant the disease viability
[DOI] 10.1002/jmv.27362 PMC 바로가기 [Article Type] Article

Emerging Insights on Caspases in COVID-19 Pathogenesis, Sequelae, and Directed Therapies

COVID-19 발병, 후유증 및 직접 요법의 카스파제에 대한 새로운 통찰력

Review

Published on 2022-02-212022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), MERS, SARS, 변종,

[키워드] accumulating activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Apoptosis apoptotic approved benefit broad spectrum caspase Caspases caused Cell cell death characterized clinical manifestation clinical manifestations Clinical use coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 current therapy cytokine cytokine release death disease disease severity downstream dysregulated effective effort Evidence expressed expression family members health emergency high risk highest highlight Hypercoagulation IL-18 IL-1β immune immune responses immunological immunological mechanism in some in vitro individual inflammasomes Inflammation inflammatory mediator Inflammatory mediators inhibitor insight Manifestations mediators multi-organ failure multiprotein complex non-immune observational studies observational study occur outcomes pathology Pathways Prevent progression pyroptosis receptor signaling respiratory risk SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe COVID-19 therapeutic therapeutic intervention upstream Vaccines variant
[DOI] 10.3389/fimmu.2022.842740 PMC 바로가기 [Article Type] Review